Nyankoi!

Junpei Kousaka's most important matters were to stay away from cats, due to his allergy to them, and his crush on his classmate Kaede Mizuno, until he accidentally damages the statue of a cat deity and is cursed with the ability to talk to cats and the task of attending 100 requests from them, with the risk of be transformed into a cat himself if he fails. The first quest he receives is to help the stray cats in the local park who have been tormented by a stranger leaving them traumatized. The tormentor later turns out to be Kaede who has an extreme fondness for cats to the point of smothering them.

Junpei must help a cat to give his thanks to a girl who helped him, however she is no other than Kanako Sumiyoshi, a childhood acquaintance of his who is determined to torment him during the school's cultural festival. The cat later moves in with Kunpei until he can find another home.

Junpei meets Chizuru Mochizuki, a postwoman in trouble and decides to help her while roaming the city helping the cats with their requests. However, hanging around with her ends up putting him on a series of misunderstandings much to his despair.

Junpei's next request is from a cat owned by Nagi Ichinose, an upperclassman of him. While Nagi seems to be a threat to his relationship with Kaede at first, he ends up being surprised when he figures out Nagi's true nature.

Junpei sets for the amusement park with Kaede, which could be the perfect chance to get closer to her if Kanako and Nagi had not come along for the ride.

Junpei meet the twins Akari and Kotone Kirishima, who know about his curse and decided to help on his ordeal. However, hanging with them becomes another source of misunderstandings, mostly due to Kotone's strange infatuation on him and their ability to sense the supernatural like Junpei's curse.

Junpei sets for a school trip to Kyoto with his classmates, but he barely has time to enjoy the trip when words about him spread among the local cats who flood him with requests. Junpei along with Kaede and Sumiyoshi soon stumble upon Ichinose who's family is situated in Kyoto and is there to attend an annual meeting. This meeting is in fact an arrangement to have Ichinose choose a husband, a decision which she would always decline.

Junpei's next task is to help a cat to get in shape in order to win the favor of his beloved. But when he starts to neglect his promise with him, the cat decides to enact revenge by putting him on a very embarrassing situation.

The gang sets for a leisure time at the swimming pool, but Junpei gets sick, and Kanako pays a visit to take care of him, while struggling about her true feelings.

The Kirishima sisters end up counting with Junpei's unexpected help to deal with a spirit who threatens his friends.

Christmas is coming and after stumbling on Junpei, Kanako ends up spending some quality time with him.

Kaede is suspicious about Junpei's secret and he must find a way to dissuade her before being stricken with the full force of his curse.